The Jarvis Lab

2024

Streicker DG, Griffiths ME, Antia R, Bergner L, Bowman P, de Moraes MVDS, Esvelt K, Famulare M, Gilbert A, He B, Jarvis MA, Kennedy DA, Kuzma J, Wanyonyi CN, Remien C, Rocke T, Rosenke K, Schreiner C, Sheen J, Simons D, Yordanova IA, Bull JJ, Nuismer SL. Developing transmissible vaccines for animal infections. Science. 2024. Apr 19;384(6693):275-277. PMID: 38669579

Knickmann J, Staliunaite L, Puhach O, Ostermann E, Günther T, Nichols J, Jarvis MA, Voigt S, Grundhoff A, Davison AJ, Brune W. A simple method for rapid cloning of complete herpesvirus genomes. Cell Rep. Methods. 2024. Feb 26;4(2):100696. PMID: 38266652

2023

de Brito RCF, Holtham K, Roser J, Saunders JE, Wezel Y, Henderson S, Mauch T, Sanz-Bernardo B, Frossard JP, Bernard M, Lean FZX, Nunez A, Gubbins S, Suárez NM, Davison AJ, Francis MJ, Huether M, Benchaoui H, Salt J, Fowler VL, Jarvis MA, Graham SP. An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection. Front Immunol. 2023. Aug 3;14:1201973. PMID: 37600784

Hansen F, Vučak M, Nichols J, Hughes J, Bane S, Camiolo S, da Silva Filipe A, Ostermann E, Staliunaite L, Chan B, Mauch T, Sogoba N, Streblow DN, Voigt S, Oestereich L, Ehlers B, Redwood AJ, Feldmann H, Brune W, Rosenke K, Jarvis MA, Davison AJ. Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis). J. Gen. Virol. 2023. Aug 104(8):001873. PMID: 37643006

Dong N, Nichols H, Sun Q, Chen X, Zheng J, Guan Z, Zhang H, Davison A, Wezel Y, Li Z, Li B, Liu K, Shao D, Qiu Y, Sun J, Li X, Upton M, Ma Z, Jarvis MA, Wei J. Bovine Herpesvirus-4 based vaccine provides protective immunity against Streptococcus suis disease in a rabbit model. Vaccines. 2023. May 20;11(5):1004. PMID: 37243109

Yan Z, Yao X, Pan R, Zhang J, Ma X, Dong N, Wei J, Liu K, Qiu Y, Sealey K, Nichols H, Jarvis MA, Upton M, Li X, Ma Z, Liu J, Li B. Subunit vaccine targeting phosphate ABC transporter ATP-binding protein, PstB, provides cross-protection against Streptococcus suis serotype 2, 7, and 9 in mice. Vet Sci. 2023. Jan 9;10(1):48. PMID: 36669049

The COVID Years (2020 to 2023)

Rosenke K, Lewis MC, Feldmann F, Bohrnsen E, Schwarz B, Okumura A, Bohler WF, Callison J, Shaia C, Bosio CM, Lovaglio J, Saturday G, Jarvis MA, Feldmann H. Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques. 2023. JCI Insight. 2023. Feb 22;8(4):e166485. PMID: 36574296

Rosenke K, Okumura A, Lewis MC, Feldmann F, Meade-White K, Bohler WF, Griffin A, Rosenke R, Shaia C, Jarvis MA, Feldmann H. Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model. JCI Insight. 2022. Jul 8;7(13):e160108. PMID: 35579953

Hansen F, Meade-White K, Clancy C, Rosenke R, Okumura A, Hawman DW, Feldmann F, Kaza B, Jarvis MA, Rosenke K, Feldmann H. SARS-CoV-2 reinfection prevents acute respiratory disease in Syrian hamsters but not replication in the upper respiratory tract. Cell Rep. 2022. Mar 15;38(11)110515 PMID: 35263638

Haddock E, Callison J, Seifert SN, Okumura A, Tang-Huau TL, Leventhal SS, Lewis MC, Lovaglio J, Hanley PW, Shaia C, Hawman DW, Munster VJ, Jarvis MA, Richt JA, Feldmann H. Three-week old pigs are not susceptible to productive infection with SARS-CoV-2. Microorganisms. 2022. Feb 10;10(2):407. PMID: 35208863

Rosenke K, Feldmann F, Okumura A, Hansen F, Tang-Huau TL, Meade-White K, Kaza B, Callison J, Lewis MC, Smith BJ, Hanley PW, Lovaglio J, Jarvis MA, Shaia C, Feldmann H. UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates. Emerg. Microbes Infect. 2021. Dec 10(1):2173-2182. PMID: 34724885

Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Barbian K, Meade-White K, Okumura A, Leventhal S, Hawman DW, Ricotta E, Bosio CM, Martens C, Saturday G, Feldmann H, Jarvis MA. Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model. Nat. Commun. 2021. Apr 16;12(1)2295. PMID: 33863887

Hansen F, Feldmann H, Jarvis MA. Targeting Ebola virus replication through pharmaceutical intervention. Expert Opin. Investigat. Drugs 2021. Mar 30(3):201-226. PMID: 33593215.  This may seem a little out place, but raises the many caveats of drug repurposing through the lens of our COVID-19 experience. 

Rosenke K, Jarvis MA, Feldmann F, Schwarz B, Okumura A, Lovaglio J, Saturday G, Hanley PW, Meade-White K, Williamson BN, Hansen F, Perez-Perez L, Leventhal S, Tang-Huau TL, Callison J, Haddock E, Stromberg KA, Scott D, Sewell G, Bosio CM, Hawman D, de Wit E, Feldmann H. Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models. JCI Insight. 2020. Dec 3;5(23):e143174. PMID: 33090972

Rosenke K, Meade-White K, Letko M, Clancy C, Hansen F, Liu Y, Okumura A, Tang-Huau TL, Li R, Saturday G, Feldmann F, Scott D, Wang Z, Munster V, Jarvis MA, Feldmann H. Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection. Emerg. Microbes Infect. 2020. Dec;9(1):2673-2684. PMID: 33251966

Jarvis MA, Hansen FA, Rosenke K, Haddock E, Rollinson C, Rule S, Sewell G, Hughes A, Feldmann H. Evaluation of drugs for potential repurposing against COVID-19 using a tier-based scoring system. Antivir. Ther. 2020. 25(4):223-231. PMID: 32744511

A Selection from Across the Years (1999 to 2019)

Schoenborn P, Osborne R, Toms N, Johnstone K, Milsom C, Muneer R, Jarvis MA, Belshaw R. OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics. BMC Med Educ. 2019 Nov 7;19(1):407. doi: 10.1186/s12909-019-1812-7. PMID: 31699073

Murthy S, O'Brien K, Agbor A, Angedakin S, Arandjelovic M, Ayimisin EA, Bailey E, Bergl RA, Brazzola G, Dieguez P, Eno-Nku M, Eshuis H, Fruth B, Gillespie TR, Ginath Y, Gray M, Herbinger I, Jones S, Kehoe L, Kühl H, Kujirakwinja D, Lee K, Madinda NF, Mitamba G, Muhindo E, Nishuli R, Ormsby LJ, Petrzelkova KJ, Plumptre AJ, Robbins MM, Sommer V, Ter Heegde M, Todd A, Tokunda R, Wessling E, Jarvis MA, Leendertz FH, Ehlers B, Calvignac-Spencer S. Cytomegalovirus distribution and evolution in hominines. Virus Evol. 2019 Aug 1;5(2):vez015. doi: 10.1093/ve/vez015. PMID: 31384482

Kolb P, Sijmons S, McArdle MR, Taher H, Womack J, Hughes C, Ventura A, Jarvis MA, Stahl-Hennig C, Hansen S, Picker LJ, Malouli D, Hengel H, Früh K. Identification and Functional Characterization of a Novel Fc Gamma-Binding Glycoprotein in Rhesus Cytomegalovirus. J Virol. 2019 Feb 5;93(4):e02077-18. doi: 10.1128/JVI.02077-18. PMID: 30487278

Hansen, S. G., D. E. Zak, G. Xu, J. C. Ford, E. E. Marshall, D. Malouli, R. M. Gilbride, C. M. Hughes, A. B. Ventura, E. Ainslie, K. T. Randall, A. N. Selseth, P. Rundstrom, L. Herlache, M. S. Lewis, H. Park, S. L. Planer, J. M. Turner, M. Fischer, C. Armstrong, R. C. Zweig, J. Valvo, J. M. Braun, S. Shankar, L. Lu, A. W. Sylwester, A. W. Legasse, M. Messerle, M. A. Jarvis, L. M. Amon, A. Aderem, G. Alter, D. J. Laddy, M. Stone, A. Bonavia, T. G. Evans, M. K. Axthelm, K. Früh, P. T. Edlefsen, and L. J. Picker. Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat. Med. 2018. doi: 10.1038/nm.4473. PMID: 29334373

Redfern KM, Cammack VL, Sweet N, Preston LA; SoBHCS Student Team, Jarvis MA, Rees GA. Nutrient-extraction blender preparation reduces postprandial glucose responses from fruit juice consumption. Nutr Diabetes. 2017 Oct 9;7(10):e288. doi: 10.1038/nutd.2017.36. PMID: 28991222

Marzi A, Murphy AA, Feldmann F, Parkins CJ, Haddock E, Hanley PW, Emery MJ, Engelmann F, Messaoudi I, Feldmann H, Jarvis MA. Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection. Scientific Reports. 2016. doi:10.1038/srep21674.   PMID: 26876974

Murphy AA, Redwood AJ and Jarvis MA. Self-disseminating vaccines for emerging infectious diseases. Expert Rev Vaccines. 2016. Jan;15(1):31-9.  PMID:26524478

Anoh AE, Akoua-Koffi C, Couacy-Hymann E, Pauly M, Schubert G, Mossoun A, Weiss S, Leendertz SA, Jarvis MA, Leendertz FH, Ehlers B. Genetic identification of cytomegaloviruses in a rural population of Côte d'Ivoire. Virol J. 2015 Oct 5;12(1):155. PMID:26437859

Katja Spiess, Mads G Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Kalpana Dulal, Tong Cheng, Gertrud M Hjortø, Olav Larsen, John S Burg, Michael A Jarvis, Kenan Garcia, Hua Zhu, Thomas N Kledal, Mette M Rosenkilde. An Engineered Chemokine-Based Toxin Targeting the Viral GPCR, US28, Potently Inhibits Cytomegalovirus Infection in vivo. PNAS USA. 2015. Jul 7;112(27):8427-32. PMID:26080445

Hill SC, Murphy AA, Cotton M, Palser AL, Benson P, Lesellier S, Gormley E, Richomme C, Grierson S, Bhuachalla D, Chambers M, Boschiroli M-L, Ehlers B, Jarvis MA and Pybus OG. Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the Polyomaviridae. J Gen Virology. 2015. Jun;96(Pt 6):1411-22. PMID:25626684

Tsuda Y, Parkins CJ, Caposio P, Feldmann F, Botto S, Ball S, Messaoudi I, Cicin-Sain L, Feldmann H, Jarvis MA. A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose. Vaccine. 2015. 33:2261. PMID:25820063

Spiess K, Fares S, Sparre-Ulrich A, Hilgenberg E, Jarvis MA, Ehlers B, and Rosenkilde M. Identification and functional comparison of 7TM G protein-coupled BILF1 receptors in recently discovered non-human primate lymphocryptoviruses. J Virology. 2015.15:2253. PMID:25505061

MacManiman JD, Meuser A, Botto S, Smith PP, Liu F, Jarvis MA, Nelson JA, Caposio P. Human Cytomegalovirus-Encoded pUL7 is a Novel CEACAM1-like Molecule Responsible form Promotion of Angiogenesis. MBio. 2014. 5:e02035. PMID:25352622

Murthy S, Couacy-Hymann E, Metzger S, Nowak K, De Nys H, Boesch C, Wittig R, Jarvis MA, Leendertz FH, Ehlers B. Absence of Frequent Herpesvirus Transmission in a Non-human Primate Predator-Prey System in the Wild. J Virology. 2013. 87:10651. PMID:23885068

Scuda N, Madinda NF, Akoua-Koffi C, Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendertz SAJ, Couacy-Hymann E, Robbins M, Boesch C, Jarvis MA, Moens U, Mugisha L, Calvignac-Spencer S, Leendertz FH, Ehlers B. Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population. PLoS Pathogens. 2013. 9:e1003429. PMID:23818846

Dekhtiarenko I, Jarvis MA, Ruzsics Z, Cicin-Sain L. The Context of Gene Expression Defines the Immunodominance Hierarchy of Cytomegalovirus Antigens. J Immunol. 2013. 190:3399. PMID:23460738

Klyushnenkova EN, Kouiavskaia DV, Caposio P, Boto S, Alexander RB, and Jarvis MA. A cytomegalovirus-based vaccine designed to enhance tumor-specific CD8+ T cells results in tumor regression in a murine model of prostate cancer. J Immunotherapy. 2012. 35:390. PMID:22576344

Tierney R, Nakai T, Parkins CJ, Caposio P, Fairweather NF, Sesardic D, Jarvis MA. A single-dose cytomegalovirus-based vaccine encoding a tetanus toxin fragment C induces sustained levels of protective tetanus antibodies in mice. Vaccine. 2012. 30:3047. PMID:22414558

Tsuda, Y, Caposio P, Parkins C, Botto S, Messaoudi I, Cicin-Sain L, Feldmann H, Jarvis MA. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against lethal Ebola virus challenge. PLoS Negl. Trop. Dis. 2011. 5:e1275. PMID:21858240

Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T, Legasse AW, Axthelm MK, Nelson JA, Jarvis MA, Piatak, Jr M, Lifson JD, Picker LJ. Profound early control of highly pathogenic SIV by an effector-memory T cell vaccine. Nature. 2011. 473:523. PMID:21562493

Hansen, SG, Powers C, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Früh K. Evasion of CD8+ T cells is critical for super-infection by cytomegalovirus. Science. 2010. 328:102. PMID:20360110

Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG, Wong SW, Barry PA, Nelson JA. A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J. Virol. 2004. Nov 78(22):12529-36. PMID: 15507640

Jarvis MA, Wang CE, Meyers HL, Smith PP, Corless CL, Henderson GJ, Vieira J, Britt WJ, Nelson JA. Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent. J. Virol. 1999. Jun 73(6):4552-60. PMID: 10233913

Jarvis MA, Levin LG, Harrison JA, DePianto DJ, Suzuki CM, Ziaja CL, Brown JE, Jolly KW, Reisner HM, Abildgaard CF, Powell JS. Induction of human factor VIII inhibitors in rats by immunization with human recombinant factor VIII: a small animal model for humans with high responder inhibiotor phenotype. Thromb. Haemost. 1996. Feb 75(2):318-25. PMID: 8815584